Dr Jaffe joined Kaiser Permanente in 1993 and in 2000 he led the design of the Kaiser Permanente Northern California Hypertension Program. In 2004 he led the creation of the Kaiser Permanente Northern California Prevent Heart Attacks and Stokes Everyday (PHASE) program that delivers cardiovascular preventive services to high-risk individuals.
From 2009 to 2017 he led the Kaiser National Integrated Cardiovascular Health Guideline Team. From 2013-2015 he consulted for the Centers for Disease Control (CDC) Global Standardization Treatment Project and from 2015 -2017 he was a technical advisor for the Pan American Health Organization Hypertension Program. From 2017 to 2019, he joined Resolve to Save Lives as the first Senior Vice President of Cardiovascular Health, with the goal of establishing programs to prevent 100 million deaths from cardiovascular disease in low and middle-income countries.
Dr Jaffe attended the University of California at Berkeley and the Baylor College of Medicine in Houston, Texas. He completed residency at the University of California, San Diego, and did his Endocrinology fellowship at the University of California, San Francisco. For 25 years he was an Associate Clinical Professor of Medicine at the University of California, San Francisco, Medical School. He is board certified in Internal Medicine and in Diabetes, Endocrinology, and Metabolism. He frequently lectures locally, nationally, and internationally on the subject of population level cardiovascular risk reduction programs.